Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENTPD5 | O75356 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067697 | 0.72 | ENTPD5 (0.53) | ENTPD5OPRM1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL10899122 | 0.71 | RARB (0.50) | ENTPD5OPRM1OPRK1OPRD1 | |
| SCHEMBL6248845 | 0.67 | PDE4D (0.42) | ENTPD5ALOX15ALDH1A1LMNACYP2C9 | |
| SCHEMBL30701838 | 0.67 | RXRA (0.49) | ALDH1A1LMNATP53CYP3A4CYP1A2 | |
| SCHEMBL7211111 | 0.67 | CYP3A4 (0.44) | ALOX15ALDH1A1LMNACYP2C9HSD17B10 | |
| SCHEMBL1360287 | 0.67 | RXRA (0.49) | ALDH1A1LMNATP53CYP3A4CYP1A2 | |
| SCHEMBL29911088 | 0.67 | CYP3A4 (0.44) | ALOX15ALDH1A1LMNACYP2C9HSD17B10 | |
| SCHEMBL2123476 | 0.65 | PDK2 (0.46) | ALDH1A1MAOBOPRM1OPRK1KDM4E | |
| SCHEMBL30956355 | 0.65 | PDK2 (0.46) | ALDH1A1MAOBOPRM1OPRK1KDM4E | |
| SCHEMBL13625257 | 0.65 | TP53 (0.44) | ALDH1A1LMNAMAOBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971601-B1 | N4-PHENYL-QUINAZOLINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | ARRAY BIOPHARMA INC (US) | 2009-10-21 | — | — | EP | disclosed |