Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144673 | 0.77 | CYP1A2 (0.53) | KMT2AMAPK1CYP1A2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28736083 | 0.76 | CYP1A2 (0.52) | KMT2AMAPK1CYP1A2L3MBTL1ALDH1A1 | |
| SCHEMBL1681771 | 0.69 | PTGS2 (0.65) | PTGS2PTPRCBCAT2 | |
| SCHEMBL10507755 | 0.68 | IDO1 (0.44) | L3MBTL1ALDH1A1KDM4ERAB9ANOTUM | |
| SCHEMBL3577075 | 0.68 | C1R (0.44) | CYP1A2CYP3A4ADORA3ADORA2AADORA1 | |
| SCHEMBL9289058 | 0.68 | PTGS2 (0.44) | PTGS2KMT2AMAPK1TP53ALOX15 | |
| SCHEMBL2350648 | 0.68 | IDO1 (0.43) | KMT2AMAPK1TP53ALOX15CYP1A2 | |
| SCHEMBL12914273 | 0.68 | KDM4E (0.45) | PTGS2MAPK1TP53ALOX15CYP1A2 | |
| SCHEMBL4245392 | 0.68 | KDM4E (0.55) | KMT2AMAPK1CYP1A2L3MBTL1ALDH1A1 | |
| SCHEMBL2782853 | 0.67 | PTGS2 (0.68) | PTGS2BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697381-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1697381-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070149553-A1 | Mitotic kinesin inhibitors | ARRINGTON KENNETH L | 2007-06-28 | — | — | US | disclosed |
| US-20070149553-A1 | Mitotic kinesin inhibitors | ARRINGTON KENNETH L | 2007-06-28 | — | — | US | disclosed |
| CN-1898249-A | Mitotic kinesin inhibitors | MERCK & CO INC (US) | 2007-01-17 | — | — | CN | disclosed |
| EP-1697381-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1697381-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061518-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061518-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149553-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18B | PTGS2 4389/4885KMT2A 310/4885MAPK1 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.