SCHEMBL4061489

SCHEMBL4061489

CN1C(=O)NC(=O)/C(=C2/C(=O)C(C(C)(C)C)=CC=C2C(C)(C)C)C1=O

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.44
ALDH1A1 P00352 2/20 0.44
ATM Q13315 2/20 0.44
MCL1 Q07820 1/20 0.44
CES2 O00748 1/20 0.30
PKM P14618 1/20 0.30
HPGD P15428 1/20 0.30
CES1 P23141 1/20 0.30
MPI P34949 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4064234 0.72
SCHEMBL2699905 0.65 ALDH1A1 (1.00) MAPTALDH1A1ATMMCL1CES2
SCHEMBL251169 0.64 MAPT (0.46) MAPTALDH1A1ATMCES1NPSR1
SCHEMBL2728471 0.63
SCHEMBL4062385 0.60 TDP2 (0.49) CES1
SCHEMBL13995655 0.56 MAPT (0.39) MAPTALDH1A1ATM
SCHEMBL4062081 0.56 CES2 (0.50) MAPTALDH1A1ATMCES2PKM
SCHEMBL11891064 0.55
SCHEMBL15906750 0.55 MAPT (0.39) MAPTALDH1A1ATMMCL1CES2
SCHEMBL5358028 0.54 ATM (0.39) MAPTALDH1A1ATMMCL1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8507162-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-08-13 US disclosed
US-8507162-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-08-13 US disclosed
EP-2447781-B1 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KK (JP) 2013-01-16 EP disclosed
US-20120107735-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2012-05-03 US disclosed
US-20120107735-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2012-05-03 US disclosed
EP-2447781-A1 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus Canon Kabushiki Kaisha (JP) 2012-05-02 EP disclosed