Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | MDH2 | P40926 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | PPARD | Q03181 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950019 | 0.90 | ALDH1A1 (0.62) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL4490807 | 0.90 | PPARG (0.71) | ALDH1A1HPGDPPARGPPARDPPARA | |
| SCHEMBL6664147 | 0.88 | ALDH1A1 (0.60) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL7123353 | 0.86 | PKM (0.62) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL16714028 | 0.83 | MDH2 (0.85) | ALDH1A1HPGDMDH2SMN1; SMN2IMPDH2 | |
| SCHEMBL22892462 | 0.82 | KMT2A (0.83) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL29402485 | 0.82 | KMT2A (0.83) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL28708925 | 0.82 | KMT2A (0.83) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL27656944 | 0.81 | PPARG (0.75) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG | |
| SCHEMBL27656942 | 0.81 | PPARG (0.75) | ALDH1A1HPGDMDH2SMN1; SMN2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655372-B1 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE INC (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2655372-A2 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ArQule, Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| US-8470786-B2 | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | ARQULE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2012088491-A2 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| US-7601751-B2 | Indole acetic acid acyl guanidines as β-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-13 | — | — | US | disclosed |
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20070054902-A1 | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists | SHIONOGI & CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070049589-A1 | Indole acetic acid acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-01 | — | — | US | disclosed |
| EP-1690538-A1 | ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | SHIONOGI & CO., LTD. (JP) | 2006-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049589-A1 | Indole acetic acid acyl guanidines as beta-secretase inhibitors | BACE1, APP, BACE2 | ALDH1A1 617/4885HPGD 1837/4885MDH2 3791/4885 |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | DHPS, PDCD5, DPYD | ALDH1A1 1136/4885HPGD 50/4885MDH2 320/4885 |
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | ALDH1A1 1836/4885HPGD 2760/4885MDH2 2736/4885 |
| US-20070054902-A1 | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists | NR1H3, NR1H2, RXRA | ALDH1A1 1698/4885HPGD 1703/4885MDH2 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.