SCHEMBL4098433

SCHEMBL4098433

O=C(O)Cc1c[nH]c2cc(F)ccc12

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.77
GPR84 Q9NQS5 3/20 0.65
HTR2A P28223 1/20 0.58
ALDH1A1 P00352 3/20 0.56
HPGD P15428 2/20 0.56
LMNA P02545 1/20 0.56
GLA P06280 1/20 0.56
CYP2C9 P11712 1/20 0.56
NFKB1 P19838 1/20 0.56
PMP22 Q01453 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
TDO2 P48775 2/20 0.54
KDM4E B2RXH2 3/20 0.51
HTR1A P08908 1/20 0.51
MEN1 O00255 2/20 0.49
MAPT P10636 2/20 0.49
KMT2A Q03164 2/20 0.49
POLB P06746 1/20 0.49
GAA P10253 1/20 0.49
THRB P10828 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29651210 1.00 TSHR (0.77) TSHRGPR84HTR2AALDH1A1HPGD
SCHEMBL2260803 0.87 TSHR (1.00) TSHRGPR84HTR2AALDH1A1HPGD
SCHEMBL1972740 0.86 GPR84 (0.63) TSHRGPR84HTR2ANPSR1TDO2
SCHEMBL25139912 0.86 GPR84 (0.63) TSHRGPR84HTR2ATDO2HTR1A
Hydrochloric Acid SCHEMBL1372337 0.86 TSHR (0.97) TSHRGPR84HTR2AALDH1A1HPGD
SCHEMBL5637957 0.84 HTR2A (0.63) TSHRGPR84HTR2AHPGDTDO2
SCHEMBL25139752 0.83 GPR84 (0.59) TSHRGPR84HTR2ATDO2HTR1A
SCHEMBL25139722 0.83 GPR84 (0.59) TSHRGPR84HTR2ATDO2HTR1A
SCHEMBL6663269 0.82 ALDH1A1 (0.77) TSHRHTR2AALDH1A1HPGDLMNA
SCHEMBL28836424 0.82 GPR84 (0.58) TSHRGPR84HTR2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119332255-A Electrochemical synthesis method of arundone derivatives 云南师范大学 2025-01-21 CN claimed
CN-118086928-A Method for electrochemical synthesis of pyrimidoindole derivative under mild condition 湘潭大学 2024-05-28 CN claimed
WO-2007127923-A2 PLANT GROWTH HORMONE REGULATED TRANSCRIPTION FACTORS AND PROMOTERS THEREOF DONALD DANFORTH PLANT SCIENCE CENTER (US) 2007-11-08 WO claimed
US-20050107258-A1 Auxinic analogues of indole-3-acetic acid Life Technologies Corporation 2005-05-19 US claimed
US-6815205-B2 GENERATING PLANT ROOTS INVITROGEN CORPORATION 2004-11-09 US claimed
US-20030087762-A1 Auxinic analogues of indole-3-acetic acid LIFE TECHNOLOGIES, INC. 2003-05-08 US claimed
US-6361999-B1 AMELIORATING DETRIMENTAL EFFECTS OF STRESS ON A PLANT OR PLANT TISSUE, SUCH AS ENVIRONMENTAL STRESS, PHYSICAL STRESS, CHEMICAL STRESS, FROM POLLUTION, CONTAMINATION, DROUGHT, AND LIGHT BY CONTACTING WITH AUXINIC INDOLE ACETIC ACID COMPOUND LIFE TECHNOLOGIES, INC. 2002-03-26 US claimed
US-12612424-B2 HPK1 inhibitors and uses thereof REGOR PHARMACEUTICALS, INC. (US) 2026-04-28 US disclosed
CN-119332255-A Electrochemical synthesis method of arundone derivatives 云南师范大学 2025-01-21 CN disclosed
CN-118086928-A Method for electrochemical synthesis of pyrimidoindole derivative under mild condition 湘潭大学 2024-05-28 CN disclosed
US-11912687-B2 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof Board of Trustees of the Southern Illinois University (US) 2024-02-27 US disclosed
US-11912687-B2 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof Board of Trustees of the Southern Illinois University (US) 2024-02-27 US disclosed
US-11912687-B2 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof Board of Trustees of the Southern Illinois University (US) 2024-02-27 US disclosed
WO-2007127923-A2 PLANT GROWTH HORMONE REGULATED TRANSCRIPTION FACTORS AND PROMOTERS THEREOF DONALD DANFORTH PLANT SCIENCE CENTER (US) 2007-11-08 WO disclosed
US-20070049589-A1 Indole acetic acid acyl guanidines as beta-secretase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2007-03-01 US disclosed
US-20050203166-A1 Indole-3-acetic acid derivatives CANCER RESEARCH TECHNOLOGY LIMITED 2005-09-15 US disclosed
US-6890948-B1 Use of indole-3-acetic acid derivatives in medicine CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2005-05-10 US disclosed
EP-1296676-B1 USE OF INDOLE-3-ACETIC ACID DERIVATIVES IN MEDICINE CANCER REC TECH LTD (GB) 2004-01-28 EP disclosed
EP-1296676-A1 USE OF INDOLE-3-ACETIC ACID DERIVATIVES IN MEDICINE Cancer Research Technology Limited (GB) 2003-04-02 EP disclosed
WO-2002002110-A1 USE OF INDOLE-3-ACETIC ACID DERIVATIVES IN MEDICINE CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2002-01-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12612424-B2 HPK1 inhibitors and uses thereof NEK11, NEK1, CSNK1A1 TSHR 1352/4885GPR84 1636/4885HTR2A 2117/4885
US-20070049589-A1 Indole acetic acid acyl guanidines as beta-secretase inhibitors BACE1, APP, BACE2 TSHR 2547/4885GPR84 319/4885HTR2A 430/4885
US-20030087762-A1 Auxinic analogues of indole-3-acetic acid AADAC, AADAT, AANAT TSHR 754/4885GPR84 2220/4885HTR2A 1642/4885
US-20050203166-A1 Indole-3-acetic acid derivatives ADCY3, GPR3, HCAR3 TSHR 823/4885GPR84 217/4885HTR2A 1690/4885
US-20050107258-A1 Auxinic analogues of indole-3-acetic acid AADAC, AADAT, AANAT TSHR 795/4885GPR84 2200/4885HTR2A 1868/4885
US-11912687-B2 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof SSTR4, SSTR5, SSTR3 TSHR 34/4885GPR84 115/4885HTR2A 165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.