Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276876 | 0.91 | ALDH1A1 (0.49) | MAPTALDH1A1MAPK1LMNAP2RX7 | |
| SCHEMBL4070780 | 0.87 | HRH3 (0.50) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL16373640 | 0.84 | P2RX7 (0.47) | MAPTALDH1A1MAPK1LMNAMEN1 | |
| SCHEMBL4070259 | 0.82 | MAPT (0.57) | MAPTALDH1A1POLBP2RX7THRB | |
| SCHEMBL14452752 | 0.82 | P2RX7 (0.58) | MAPTLMNAP2RX7THRBTP53 | |
| SCHEMBL14302718 | 0.79 | TP53 (0.49) | MAPTP2RX7THRBTP53 | |
| SCHEMBL7727307 | 0.77 | CYP1A2 (0.57) | ALDH1A1MAPK1MEN1KMT2ASLC6A3 | |
| SCHEMBL6478479 | 0.77 | CYP1A2 (0.57) | ALDH1A1MAPK1MEN1KMT2ASLC6A3 | |
| SCHEMBL16333179 | 0.77 | CYP1A2 (0.57) | ALDH1A1MAPK1MEN1KMT2ASLC6A3 | |
| SCHEMBL14438348 | 0.77 | ALDH1A1 (0.47) | MAPTALDH1A1MAPK1LMNAP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |