Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16373640 | 0.86 | P2RX7 (0.47) | MAPTPOLBTSHRTP53THRB | |
| SCHEMBL4061635 | 0.86 | MAPT (0.43) | MAPTPOLBTSHRTP53 | |
| SCHEMBL14452752 | 0.85 | P2RX7 (0.58) | MAPTTP53THRBP2RX7 | |
| SCHEMBL8276876 | 0.84 | ALDH1A1 (0.49) | MAPTTP53THRBP2RX7ALDH1A1 | |
| SCHEMBL4067418 | 0.83 | MAPT (0.42) | MAPTPOLBTP53P2RX7ALDH1A1 | |
| SCHEMBL4063226 | 0.82 | MAPT (0.56) | MAPTPOLBTP53THRBP2RX7 | |
| SCHEMBL14302718 | 0.81 | TP53 (0.49) | MAPTTP53THRBP2RX7 | |
| SCHEMBL11494209 | 0.74 | MAPT (0.45) | MAPTPOLBTSHRTP53THRB | |
| SCHEMBL11494210 | 0.74 | MAPT (0.45) | MAPTPOLBTSHRTP53THRB | |
| SCHEMBL14302716 | 0.74 | ALDH1A1 (0.69) | MAPTPOLBTSHRTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |