Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064073 | 0.87 | S1PR1 (0.50) | MEN1KMT2ANPC1RAB9AKIT | |
| SCHEMBL4063294 | 0.85 | MEN1 (0.53) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL4063306 | 0.79 | L3MBTL1 (0.51) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL4068903 | 0.78 | NPC1 (0.51) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL4061179 | 0.78 | NPC1 (0.56) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL4060806 | 0.77 | JAK2 (0.55) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL2950646 | 0.77 | KIT (0.77) | KITS1PR1KCNQ3KCNQ2 | |
| SCHEMBL25143492 | 0.76 | HPGD (0.63) | NPC1RAB9AL3MBTL1MAPK1TP53 | |
| SCHEMBL31665584 | 0.76 | HPGD (0.63) | NPC1RAB9AL3MBTL1MAPK1TP53 | |
| SCHEMBL5486398 | 0.75 | CYP1A2 (0.46) | MEN1KMT2ANPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |