Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 16/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064772 | 0.91 | KDM1A (0.42) | SLC6A2SLC6A4KDM1ANR1H2NR1H3 | |
| SCHEMBL4062683 | 0.82 | GPR119 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3605054 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4063156 | 0.80 | GPR119 (0.51) | SLC6A2SLC6A4 | |
| SCHEMBL4565495 | 0.77 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2NR1H2 | |
| SCHEMBL4058421 | 0.76 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4565604 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4059662 | 0.75 | GPR119 (0.53) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3616311 | 0.75 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3600086 | 0.75 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |