Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064766 | 0.91 | SLC6A2 (0.48) | KDM1ANR1H2NR1H3SLC6A2SLC6A4 | |
| SCHEMBL4062687 | 0.82 | GPR119 (0.55) | GPR119TP53 | |
| SCHEMBL3605057 | 0.80 | HTR6 (0.47) | KDM1AGPR119SLC6A2SLC6A4 | |
| SCHEMBL4063161 | 0.80 | GPR119 (0.52) | GPR119TP53 | |
| SCHEMBL4058427 | 0.76 | GPR119 (0.46) | GPR119TP53 | |
| SCHEMBL6609250 | 0.75 | CHEK2 (0.56) | KDM1AATMCHEK2PRMT5OPRD1 | |
| SCHEMBL4059665 | 0.75 | GPR119 (0.53) | GPR119TP53 | |
| SCHEMBL3616317 | 0.75 | GPR119 (0.43) | GPR119TP53 | |
| SCHEMBL3600088 | 0.75 | CHRM2 (0.46) | GPR119 | |
| SCHEMBL6612547 | 0.74 | NPC1 (0.57) | KDM1AATMGPR119CHEK2PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |