Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072207 | 0.89 | ADRB1 (0.50) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL4071775 | 0.88 | ADRB1 (0.62) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL10478296 | 0.85 | ADRB1 (0.56) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL2048248 | 0.84 | ADRB1 (0.53) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL10118836 | 0.79 | ADRB1 (0.61) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL11503970 | 0.78 | ALDH1A1 (0.64) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL4291189 | 0.78 | ADRB1 (0.72) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL29738225 | 0.78 | ALDH1A1 (0.64) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL4065961 | 0.78 | ADRB1 (0.52) | ADRB1ALDH1A1LMNAAKR1C3TSHR | |
| Hydrochloric Acid SCHEMBL1609111 | 0.77 | ADRB1 (0.59) | ADRB1ALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |