Hydrochloric Acid

Hydrochloric Acid

SCHEMBL4065888

CCC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Zr+2].[Cl-].[Cl-]

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 2/20 0.32
SLC6A3 known ✓ Q01959 2/20 0.32
HTR7 P34969 3/20 0.35
HTR1A P08908 2/20 0.33
SLC6A4 P31645 6/20 0.33
DRD2 P14416 1/20 0.33
HTR2C P28335 2/20 0.32
MTNR1A P48039 1/20 0.32
CYP2D6 P10635 1/20 0.32
EDNRB P24530 1/20 0.32
EDNRA P25101 1/20 0.32
KDM4E B2RXH2 3/20 0.31
TDP2 O95551 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
MAPK1 P28482 1/20 0.31
CASP3 P42574 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27504589 0.90 DNMT1 (0.35) HTR7HTR1ASLC6A4KDM4EALDH1A1
Hydrochloric Acid SCHEMBL27478889 0.89 SLC6A4 (0.36) HTR7SLC6A4DRD2HTR2CSLC6A2
Hydrochloric Acid SCHEMBL27493411 0.88 ALDH1A1 (0.36) ALDH1A1HPGDMAPK1L3MBTL1
Hydrochloric Acid SCHEMBL5688269 0.87 CNR1 (0.37) HTR7SLC6A4DRD2ALOX15CNR2
Hydrochloric Acid SCHEMBL27477209 0.86 CNR1 (0.41) HTR7SLC6A4DRD2HTR2CSLC6A2
Hydrochloric Acid SCHEMBL7196605 0.85 KDM4E (0.41) HTR7HTR1ASLC6A4DRD2MTNR1A
Hydrochloric Acid SCHEMBL27493033 0.85 SLC22A12 (0.32) SLC6A4SLC6A2SLC6A3CYP2D6MAPT
Hydrochloric Acid SCHEMBL27476742 0.85 NPC1 (0.33) SLC6A4SLC6A2SLC6A3CYP2D6MAPT
Hydrochloric Acid SCHEMBL27514944 0.85 HTR1A (0.37) HTR7HTR1ASLC6A4
Hydrochloric Acid SCHEMBL27478891 0.85 CNR1 (0.42) HTR7SLC6A4DRD2HTR2CSLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7618912-B2 Preparation of supported catalyst systems BASELL POLYOLEFINE GMBH (DE) 2009-11-17 US claimed
US-7205363-B2 Using fluorided silica supported metallocene catalyst system and antistatic agent selected from polysulfone copolymer, polyamine, oil soluble sulfonic acid or mixture, for homo or copolymerization of propylene EXXON MOBIL CHEMICAL PATENTS INC. (US) 2007-04-17 US claimed
US-20040254316-A1 Polymerization processes using antistatic agents EXXONMOBIL CHEMICAL PATENTS INC. 2004-12-16 US claimed
US-6667272-B2 Metallocene, an activator and a fluorided support; use as alpha-olefin polymerization catalysts, polypropylene EXXONMOBIL CHEMICAL PATENTS INC. 2003-12-23 US claimed
US-6664348-B2 Metallocene catalyst such as dimethylsilandiylbis(2-ethyl-4-phenyl-1-indenyl)zirconium dimethyl for polymerization of propylene EXXONMOBIL CHEMICAL PATENTS INC. 2003-12-16 US claimed
US-6524988-B2 Metallocene, an activator and a fluorided support; polymerization catalyst EXXONMOBIL CHEMICAL PATENTS INC. 2003-02-25 US claimed
US-20020160914-A1 Highly active supported catalyst compositions EXXONMOBIL CHEMICAL PATENTS INC. 2002-10-31 US claimed
US-20010051698-A1 Highly active supported catalyst compositions EXXONMOBIL CHEMICAL PATENTS INC. 2001-12-13 US claimed
US-7521507-B2 Polypropylene-based adhesive compositions EXXONMOBIL CHEMICAL PATENTS INC. (US) 2009-04-21 US disclosed
EP-2045304-A2 Polypropylene-Based Adhesive Compositions ExxonMobil Chemical Patents Inc. (US) 2009-04-08 EP disclosed
EP-1311593-B1 POLYPROPYLENE FILMS EXXONMOBIL CHEM PATENTS INC (US) 2009-01-07 EP disclosed
US-7205363-B2 Using fluorided silica supported metallocene catalyst system and antistatic agent selected from polysulfone copolymer, polyamine, oil soluble sulfonic acid or mixture, for homo or copolymerization of propylene EXXON MOBIL CHEMICAL PATENTS INC. (US) 2007-04-17 US disclosed
EP-1315858-B1 POLYPROPYLENE FIBERS AND FABRICS EXXONMOBIL CHEM PATENTS INC (US) 2007-02-07 EP disclosed
EP-1237957-B1 PREPARATION OF SUPPORTED POLYMERIZATION CATALYSTS EXXONMOBIL CHEM PATENTS INC (US) 2006-08-23 EP disclosed
US-20020019507-A1 Polypropylene-based adhesive compositions EXXONMOBIL CHEMICAL PATENTS INC. 2002-02-14 US disclosed
US-20010051698-A1 Highly active supported catalyst compositions EXXONMOBIL CHEMICAL PATENTS INC. 2001-12-13 US disclosed
US-20010049331-A1 SUPPORTED ORGANOMETALLIC CATALYSTS AND THEIR USE IN OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. 2001-12-06 US disclosed
WO-2001036499-A1 PREPARATION OF SUPPORTED POLYMERIZATION CATALYSTS EXXON CHEMICAL PATENTS INC. (US) 2001-05-25 WO disclosed
CN-1246871-A Propylene polymers incorporating polyethylene macromers EXXON CHEMICAL PATENTS INC (US) 2000-03-08 CN disclosed
CN-1160055-A Process for reducing by-product in product mixture HOECHST AG (DE) 1997-09-24 CN disclosed