Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 4/20 | 0.58 |
| ▸ | LAP3 | P28838 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 9/20 | 0.51 |
| ▸ | IL1RN | P18510 | 1/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068036 | 1.00 | REN (0.62) | RENLTA4HLAP3MMP9MMP8 | |
| SCHEMBL4069710 | 0.85 | MMP1 (0.56) | MMP9MMP8CCR1 | |
| SCHEMBL4058892 | 0.83 | CCR1 (0.53) | CCR1SMN1; SMN2 | |
| SCHEMBL7591101 | 0.83 | CCR1 (0.53) | CCR1SMN1; SMN2 | |
| SCHEMBL8892873 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 | |
| SCHEMBL8892764 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 | |
| SCHEMBL8892865 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 | |
| SCHEMBL8892421 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 | |
| SCHEMBL8892768 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 | |
| SCHEMBL8892426 | 0.82 | LTA4H (0.64) | RENLTA4HLAP3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |