Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064685 | 0.85 | ALDH1A1 (0.46) | TSHRLMNAKMT2AKDM4EPOLB | |
| SCHEMBL4075667 | 0.84 | KDM4E (0.50) | GAAHTTLMNAKMT2AKDM4E | |
| SCHEMBL3884249 | 0.78 | NOTUM (0.56) | NOTUMTRPV1GAATSHRHTT | |
| SCHEMBL4068051 | 0.78 | LMNA (0.55) | GAATSHRLMNANAPRTCHRNB2 | |
| SCHEMBL3159549 | 0.77 | NOTUM (0.48) | NOTUMTRPV1GAATSHRHTT | |
| SCHEMBL12172748 | 0.77 | KDM4E (0.48) | NOTUMTRPV1GAAHTTPOLQ | |
| SCHEMBL965251 | 0.75 | NOTUM (0.51) | NOTUMTRPV1GAATSHRHTT | |
| SCHEMBL7742675 | 0.75 | LMNA (0.56) | NOTUMTRPV1GAATSHRHTT | |
| SCHEMBL25417551 | 0.75 | NOTUM (0.46) | NOTUMTRPV1GAATSHRHTT | |
| SCHEMBL12189450 | 0.75 | NOTUM (0.46) | NOTUMTRPV1GAATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |