Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064685 | 0.89 | ALDH1A1 (0.46) | KDM4EKMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4076883 | 0.85 | L3MBTL1 (0.41) | KDM4EKMT2AROCK2ROCK1 | |
| SCHEMBL4067161 | 0.84 | NOTUM (0.47) | KDM4EKMT2AHTTLMNAGPR52 | |
| SCHEMBL28688417 | 0.79 | TRPM8 (0.48) | SMN1; SMN2ALDH1A1LMNAMAPK1MAPT | |
| SCHEMBL4067169 | 0.78 | POLB (0.48) | KDM4EKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27841533 | 0.77 | NPC1 (0.44) | KMT2AALDH1A1CYP2C19RAB9A | |
| SCHEMBL2202453 | 0.76 | KDM4E (0.54) | KDM4EKMT2AALDH1A1LMNAROCK2 | |
| SCHEMBL2202823 | 0.74 | KDM4E (0.62) | KDM4EKMT2AHTTALDH1A1LMNA | |
| SCHEMBL4064579 | 0.72 | NPC1 (0.58) | KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3133352 | 0.72 | ALDH1A1 (0.39) | KDM4EHTTSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |