Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075667 | 0.89 | KDM4E (0.50) | ALDH1A1LMNAKMT2AKDM4ERAB9A | |
| SCHEMBL28688417 | 0.86 | TRPM8 (0.48) | ALDH1A1LMNANPC1RAB9ATRPM8 | |
| SCHEMBL4067161 | 0.85 | NOTUM (0.47) | LMNAKMT2APOLBKDM4ETSHR | |
| SCHEMBL27841533 | 0.83 | NPC1 (0.44) | ALDH1A1KMT2ANPC1RAB9ACA12 | |
| SCHEMBL11477629 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNAFAAHPHGDHMGLL | |
| SCHEMBL4064579 | 0.79 | NPC1 (0.58) | ALDH1A1MGLLKMT2APOLBNPC1 | |
| SCHEMBL4067169 | 0.78 | POLB (0.48) | ALDH1A1LMNAKMT2APOLBKDM4E | |
| SCHEMBL4327640 | 0.77 | MEN1 (0.44) | ALDH1A1KMT2ANPC1RAB9ACA12 | |
| SCHEMBL3136211 | 0.77 | NPC1 (0.40) | KMT2ANPC1RAB9ACA12CA9 | |
| SCHEMBL1185399 | 0.75 | KMT2A (0.47) | ALDH1A1LMNAFAAHPHGDHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |