Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075051 | 0.85 | MAPK13 (0.41) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL4470547 | 0.76 | CDC7 (0.33) | — | |
| SCHEMBL4067495 | 0.75 | IGF1R (0.43) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL4077928 | 0.71 | NTRK1 (0.49) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL4165509 | 0.70 | NTRK1 (0.47) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL4072134 | 0.68 | NTRK1 (0.48) | NTRK1 | |
| SCHEMBL4071743 | 0.67 | NTRK1 (0.47) | NTRK1 | |
| SCHEMBL30010241 | 0.67 | NTRK1 (0.52) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL2209333 | 0.67 | IGF1R (0.38) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL2207551 | 0.67 | IGF1R (0.38) | IGF1RNTRK1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194606-A1 | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer | ASTRAZENECA (SE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194606-A1 | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer | TYMS, TYMP, DPYD | IGF1R 2689/4885NTRK1 4196/4885MAPK13 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.