SCHEMBL862827

SCHEMBL862827

O=C(ON1C(=O)CCC1=O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.57
NR4A2 P43354 1/20 0.57
NR4A3 Q92570 1/20 0.57
NAAA Q02083 1/20 0.55
MAOB P27338 1/20 0.55
PARP10 Q53GL7 1/20 0.55
SRD5A2 P31213 1/20 0.54
PLA2G4B P0C869 1/20 0.51
CHRNB2 P17787 1/20 0.49
CHRNA5 P30532 1/20 0.49
CHRNA7 P36544 1/20 0.49
CHRNA4 P43681 1/20 0.49
EGFR P00533 3/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MAPT P10636 1/20 0.49
KMT2A Q03164 1/20 0.49
NPC1 O15118 1/20 0.49
CASP3 P42574 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL863028 0.88 MEN1 (0.55) NR4A1NR4A2NR4A3NAAAMAOB
SCHEMBL7272960 0.85 PLA2G4B (0.54) PLA2G4BMEN1MAPTKMT2ANPC1
SCHEMBL10041303 0.83 LMNA (0.47) SRD5A2MEN1ALDH1A1KMT2ACASP3
SCHEMBL6705699 0.81 NAAA (0.50) NAAAPARP10SRD5A2CHRNB2CHRNA7
SCHEMBL133554 0.81 KMT2A (0.53) ALDH1A1MAPTKMT2ANPC1RAB9A
SCHEMBL19309377 0.81 KMT2A (0.53) ALDH1A1MAPTKMT2ANPC1RAB9A
SCHEMBL25922305 0.80 MAOB (0.50) MAOBFAAHLMNA
SCHEMBL12086394 0.80 LMNA (0.54) PARP10PLA2G4BALDH1A1MAPTKMT2A
SCHEMBL406877 0.80 KMT2A (0.52) NAAASRD5A2CHRNB2CHRNA5CHRNA7
SCHEMBL5551769 0.80 LMNA (0.42) NR4A1NR4A2NR4A3NAAAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8143366-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2012-03-27 US disclosed
US-20100081782-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME EKWURIBE NNOCHIRI N 2010-04-01 US disclosed
US-7625995-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2009-12-01 US disclosed
US-20080146778-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME BIOCON LIMITED (IN) 2008-06-19 US disclosed
US-7335751-B2 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same BIOCON LIMITED (IN) 2008-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146778-A1 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME ALK, AOX1, OGFR NR4A1 964/4885NR4A2 1535/4885NR4A3 1227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.