Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068973 | 0.87 | TYK2 (0.46) | RAB9AGRM4TYK2 | |
| SCHEMBL4070581 | 0.84 | POLB (0.46) | RAB9AHPGDCYP3A4TYK2 | |
| SCHEMBL25143492 | 0.75 | HPGD (0.63) | NPC1RAB9ADHODHL3MBTL1CYP1A2 | |
| SCHEMBL31665584 | 0.75 | HPGD (0.63) | NPC1RAB9ADHODHL3MBTL1CYP1A2 | |
| SCHEMBL437874 | 0.74 | CYP3A4 (0.48) | NPC1RAB9AGRM4KDM4ESTAT1 | |
| SCHEMBL4072365 | 0.73 | KMT2A (0.51) | NPC1RAB9ADHODHL3MBTL1CYP1A2 | |
| SCHEMBL4068770 | 0.73 | NPC1 (0.50) | NPC1RAB9AGRM4DHODHL3MBTL1 | |
| SCHEMBL4248872 | 0.71 | GRM4 (0.52) | NPC1RAB9AGRM4DHODHL3MBTL1 | |
| SCHEMBL4063742 | 0.70 | DHODH (0.53) | NPC1RAB9AGRM4KDM4EDHODH | |
| SCHEMBL2119568 | 0.70 | HPGD (0.74) | NPC1RAB9ADHODHL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |