Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28413811 | 0.82 | — | — | |
| Pyridine SCHEMBL9403576 | 0.80 | TSHR (0.53) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL18279121 | 0.78 | — | — | |
| Pyridine SCHEMBL93456 | 0.76 | TSHR (0.64) | TSHRNAPRTTDP1 | |
| Benzene SCHEMBL28903529 | 0.76 | TSHR (0.64) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL7904130 | 0.74 | — | — | |
| Pyridine SCHEMBL25300535 | 0.73 | — | — | |
| Pyridine SCHEMBL2955429 | 0.73 | — | — | |
| Pyridine SCHEMBL5508547 | 0.73 | — | — | |
| Pyridine SCHEMBL7938666 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556172-B2 | Processes for the manufacture of propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl)-amide | HOFFMAN LA-ROCHE INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160083378-A1 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID (3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-b]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL)-AMIDE | HOFFMANN LA ROCHE (US) | 2016-03-24 | — | — | US | disclosed |
| US-9150594-B2 | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide | HOFFMANN-LA ROCHE INC. (US) | 2015-10-06 | — | — | US | disclosed |
| EP-2595958-B1 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE | HOFFMANN LA ROCHE (CH) | 2015-04-29 | — | — | EP | disclosed |
| US-20140288308-A1 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID -AMIDE | HOFFMANN LA ROCHE (US) | 2014-09-25 | — | — | US | disclosed |
| US-8779150-B2 | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide | HOFFMANN-LA ROCHE INC. (US) | 2014-07-15 | — | — | US | disclosed |
| EP-2595958-A2 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| US-20120022258-A1 | Novel Processes for the manufacture of Propane-1-sulfonic acid -amide | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-26 | — | — | US | disclosed |
| WO-2012010538-A2 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288308-A1 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID -AMIDE | SULT1A1, FASN, COASY | TSHR 3835/4885NAPRT 489/4885TDP1 4388/4885 |
| US-20160083378-A1 | NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID (3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-b]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL)-AMIDE | ALDH18A1, PFAS, PCCA | TSHR 3806/4885NAPRT 899/4885TDP1 4127/4885 |
| US-20120022258-A1 | Novel Processes for the manufacture of Propane-1-sulfonic acid -amide | SULT1A1, FASN, COASY | TSHR 3835/4885NAPRT 489/4885TDP1 4388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.