Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456749 | 1.00 | TP53 (0.48) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL7460990 | 1.00 | TP53 (0.48) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL25858165 | 0.81 | TP53 (0.50) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL9373403 | 0.81 | TP53 (0.50) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL8395600 | 0.81 | TP53 (0.50) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL20131003 | 0.79 | TP53 (0.53) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL11452909 | 0.79 | ADRA2C (0.51) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL7453698 | 0.79 | ADRA2C (0.51) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL28163903 | 0.79 | LMNA (0.44) | TP53LMNAHTTTSHRALDH1A1 | |
| SCHEMBL6033033 | 0.78 | TP53 (0.47) | TP53LMNAHTTTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038041-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | Myriad Genetics, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007134298-A2 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER | MYRIAD GENETICS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
| EP-0763513-B1 | Production of optically active 2-halo-1-(substituted phenyl)-ethanol and substituted styrene oxide | NIHON NOHYAKU CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |