Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16954723 | 0.84 | ALDH1A1 (0.40) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL5000481 | 0.80 | TP53 (0.52) | TP53LMNAHTTTSHRADRA2C | |
| SCHEMBL16953064 | 0.79 | GABRA1 (0.42) | TP53LMNAHTTTSHRKMT2A | |
| SCHEMBL8395600 | 0.79 | TP53 (0.50) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL16953761 | 0.78 | PSEN1 (0.39) | LMNAHTTADRA2CIDO1KMT2A | |
| SCHEMBL7460990 | 0.78 | TP53 (0.48) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL11452909 | 0.78 | ADRA2C (0.51) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL7456749 | 0.78 | TP53 (0.48) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL7453698 | 0.78 | ADRA2C (0.51) | TP53LMNAHTTTSHRHSD17B10 | |
| SCHEMBL4069342 | 0.78 | TP53 (0.48) | TP53LMNAHTTTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732919-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2006-12-20 | — | — | EP | claimed |
| WO-2005095386-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2005-10-13 | — | — | WO | claimed |