Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 1/20 | 0.46 |
| ▸ | RRM2 | P31350 | 1/20 | 0.46 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6454171 | 0.80 | GRM4 (0.41) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL29385675 | 0.80 | MKNK1 (0.49) | GRM4MAPTL3MBTL1CYP3A4CYP1A2 | |
| SCHEMBL699068 | 0.80 | MKNK1 (0.49) | GRM4MAPTL3MBTL1CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7958246 | 0.78 | GRM4 (0.40) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL20558075 | 0.77 | GRM4 (0.49) | GRM4MAPTL3MBTL1HSP90AA1HSP90AB1 | |
| SCHEMBL27543664 | 0.77 | MAPT (0.47) | MAPTL3MBTL1CYP3A4CYP1A2BLM | |
| SCHEMBL8847897 | 0.77 | EGLN2 (0.44) | MAPTL3MBTL1HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL7960810 | 0.77 | RRM1 (0.39) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL6461091 | 0.77 | RRM1 (0.39) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL7960813 | 0.77 | RRM1 (0.39) | RRM1RRM2RRM2BCISD1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822127-B2 | GAK modulators as antivirals | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-11-21 | — | — | US | disclosed |
| US-20170152271-A1 | GAK MODULATORS AS ANTIVIRALS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2017-06-01 | — | — | US | disclosed |
| US-9518066-B2 | GAK modulators | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2016-12-13 | — | — | US | disclosed |
| EP-3016958-A1 | NOVEL GAK MODULATORS | Katholieke Universiteit Leuven (BE) | 2016-05-11 | — | — | EP | disclosed |
| US-20160122364-A1 | NOVEL GAK MODULATORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2016-05-05 | — | — | US | disclosed |
| WO-2016012536-A1 | GAK MODULATORS AS ANTIVIRALS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2016-01-28 | — | — | WO | disclosed |
| WO-2015001076-A1 | NOVEL GAK MODULATORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2015-01-08 | — | — | WO | disclosed |
| EP-1381366-B9 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-1381366-B1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1381366-A4 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6825201-B2 | ANTIVIRAL ACTIVITY; TREATMENT OF HIV AND AIDS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-30 | — | — | US | disclosed |
| EP-1381366-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030096825-A1 | Indole, azaindole and related heterocyclic amidopiperazine derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2003-05-22 | — | — | US | disclosed |
| WO-2002085301-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122364-A1 | NOVEL GAK MODULATORS | GAK, CAMKK2, GRK3 | RRM1 2958/4885RRM2 1803/4885RRM2B 1486/4885 |
| US-20170152271-A1 | GAK MODULATORS AS ANTIVIRALS | GAK, IRF3, EIF2AK2 | RRM1 1634/4885RRM2 1109/4885RRM2B 1044/4885 |
| US-20030096825-A1 | Indole, azaindole and related heterocyclic amidopiperazine derivatives | IDO1, IDO2, INMT | RRM1 4481/4885RRM2 3547/4885RRM2B 4065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.