Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92707 | 0.79 | MAOA (0.56) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL18459121 | 0.79 | KDM4E (0.44) | MAOAMAOBTDP1KDM4EALDH1A1 | |
| SCHEMBL29389300 | 0.79 | MAOA (0.56) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL856788 | 0.77 | TDP1 (0.54) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL29461212 | 0.77 | TDP1 (0.54) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL4069704 | 0.77 | PARP1 (0.37) | MAOAMAOBMETAP1TDP1LMNA | |
| SCHEMBL516091 | 0.76 | TDP1 (0.59) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL18574483 | 0.76 | GPR3 (0.59) | MAOAMAOBTDP1KDM4EALDH1A1 | |
| SCHEMBL25463097 | 0.76 | MAOA (0.52) | MAOAMAOBMETAP1PDE4APDE4B | |
| SCHEMBL8128619 | 0.76 | DCPS (0.63) | MAOAMAOBMETAP1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018114700-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2018-06-28 | — | — | WO | disclosed |
| CN-103814020-B | Therapeutic activity composition and their application method | 安吉奥斯医药品有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-104513231-A | Synthetic method for lapatinib and lapatinib intermediates | ARROMAX PHARMACEUTICAL TECHNOLOGY SUZHOU CO LTD | 2015-04-15 | — | — | CN | disclosed |