Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063476 | 0.87 | MBTD1 (0.46) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL14452054 | 0.84 | POLB (0.52) | MAPTALDH1A1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL4070259 | 0.83 | MAPT (0.57) | MAPTALDH1A1TP53POLBP2RX7 | |
| SCHEMBL8276876 | 0.83 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EHSD17B10CYP3A4 | |
| SCHEMBL8251020 | 0.77 | MBTD1 (0.59) | ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL14302716 | 0.76 | ALDH1A1 (0.69) | MAPTALDH1A1KDM4EHSD17B10CYP3A4 | |
| SCHEMBL16373640 | 0.76 | P2RX7 (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4063226 | 0.75 | MAPT (0.56) | MAPTALDH1A1SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL14452752 | 0.74 | P2RX7 (0.58) | MAPTLMNATP53P2RX7 | |
| SCHEMBL2956428 | 0.73 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |