Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986474 | 0.83 | KDR (0.54) | MAPK1TSHRHSD17B10MCL1HPGD | |
| SCHEMBL14964882 | 0.72 | FGFR1 (0.53) | MAPK1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL3979887 | 0.70 | KDR (0.67) | MCL1ALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL3981493 | 0.69 | KDR (0.50) | MAPK1MCL1HPGDKDM4EKMT2A | |
| SCHEMBL3978118 | 0.67 | KDR (0.55) | MCL1HPGDKDM4EKMT2APOLB | |
| SCHEMBL28297480 | 0.67 | ACACA (0.48) | MAPK1TSHRHSD17B10MCL1ALDH1A1 | |
| SCHEMBL3977506 | 0.65 | KDR (0.59) | MCL1ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL30700550 | 0.64 | DHFR (0.41) | ALDH1A1KDM4EMAPTKMT2ALMNA | |
| SCHEMBL2367997 | 0.64 | LMNA (0.49) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL2368915 | 0.64 | SMN1; SMN2 (0.38) | MAPK1TSHRHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051982-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |