Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368915 | 0.79 | SMN1; SMN2 (0.38) | LMNAMEN1KMT2ASMN1; SMN2DYRK1A | |
| SCHEMBL30700550 | 0.79 | DHFR (0.41) | LMNAKMT2ASMN1; SMN2PRKD3MAP4K4 | |
| SCHEMBL2368808 | 0.76 | LMNA (0.55) | LMNAMEN1KMT2ACSNK2A2CSNK2B | |
| SCHEMBL2368684 | 0.76 | HTT (0.58) | LMNAMEN1KMT2ACSNK2A2CSNK2B | |
| SCHEMBL2368931 | 0.76 | DGAT1 (0.55) | LMNAKMT2ASMN1; SMN2L3MBTL1PRKD3 | |
| SCHEMBL14964882 | 0.76 | FGFR1 (0.53) | LMNACSNK2A2CSNK2BCSNK2A1SMN1; SMN2 | |
| SCHEMBL8274148 | 0.75 | MRGPRX1 (0.33) | SMN1; SMN2AURKAMAP4K4ABL1NTRK1 | |
| SCHEMBL30362436 | 0.75 | MRGPRX1 (0.33) | SMN1; SMN2AURKAMAP4K4ABL1NTRK1 | |
| SCHEMBL2368646 | 0.74 | CYP1A2 (0.51) | LMNAMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2368752 | 0.74 | PKM (0.53) | LMNAMEN1KMT2APKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |