Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.34 |
| ▸ | FCER2 | P06734 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.33 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.33 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.33 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.33 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.33 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.33 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063820 | 0.89 | KDM4E (0.37) | CYP2C19PLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4062969 | 0.87 | ADRA1D (0.36) | EPHX1PLA2G10PLA2G2ASLC1A1 | |
| SCHEMBL4060239 | 0.85 | EPHX1 (0.40) | EPHX1PLA2G10PLA2G2APLA2G5 | |
| SCHEMBL4070172 | 0.84 | KMT2A (0.33) | EPHX1PLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4061937 | 0.81 | HMGB1 (0.34) | CYP3A4CYP2C19EPHX1PLA2G10PLA2G2A | |
| SCHEMBL4064865 | 0.80 | TDP1 (0.38) | PSMB5EPHX1SLC1A1 | |
| SCHEMBL4064377 | 0.80 | ADRA1D (0.35) | EPHX1PLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL7681396 | 0.79 | AKR1B1 (0.37) | EPHX1SLC1A1 | |
| SCHEMBL4070496 | 0.78 | HMGB1 (0.39) | PLA2G10PLA2G2APLA2G1BPLA2G5PLA2G2C | |
| SCHEMBL4070562 | 0.78 | PLA2G10 (0.39) | PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-20020198207-A1 | Novel Hexanoic acid derivatives | KATH JOHN CHARLES (US) | 2002-12-26 | — | — | US | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198207-A1 | Novel Hexanoic acid derivatives | HCAR3, HCAR1, FFAR1 | CYP3A4 1637/4885CYP2C19 3140/4885PSMB5 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.