Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11809457 | 0.89 | MAOA (0.45) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL29746219 | 0.80 | AR (0.46) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL398104 | 0.80 | AR (0.46) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL601707 | 0.80 | TAAR1 (0.47) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL4069431 | 0.77 | AR (0.44) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL399673 | 0.77 | ALDH1A1 (0.49) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL20809062 | 0.76 | RAB9A (0.42) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL20809321 | 0.76 | DHODH (0.51) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL10039876 | 0.75 | RAB9A (0.55) | RAB9ANPC1ARCYP3A4CYP2C9 | |
| SCHEMBL20809323 | 0.74 | RAB9A (0.38) | RAB9ANPC1ARCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051982-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |