SCHEMBL4070845

SCHEMBL4070845

COc1nc(C)c(-c2ccccc2)c(C)c1C#N.COc1nc(C)c(I)c(C)c1C#N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SQOR Q9Y6N5 7/20 0.49
HTT P42858 3/20 0.46
ADORA2A P29274 2/20 0.46
HSD17B10 Q99714 2/20 0.46
ADRA2A P08913 1/20 0.46
RXFP1 Q9HBX9 2/20 0.40
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 6/20 0.39
NPC1 O15118 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HPGD P15428 2/20 0.38
ADORA1 P30542 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
RECQL P46063 1/20 0.38
PPARG P37231 1/20 0.37
NCOA2 Q15596 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4072588 0.92 SQOR (0.56) SQORHTTADORA2AHSD17B10ADRA2A
SCHEMBL4075864 0.83 RECQL (0.46) SQORHTTKDM4EALDH1A1GAA
SCHEMBL4071993 0.75 RECQL (0.54) HSD17B10KDM4EALDH1A1GAACYP1A2
SCHEMBL4475072 0.73 SQOR (0.51) SQORHTTADORA2AHSD17B10ADRA2A
SCHEMBL11008493 0.72 HTT (0.59) HTTADORA2AHSD17B10ADRA2ARXFP1
SCHEMBL11037564 0.72 HSD17B10 (0.77) HTTADORA2AHSD17B10ADRA2ARXFP1
SCHEMBL4064361 0.71 SQOR (0.45) SQORHTTHSD17B10KDM4EALDH1A1
SCHEMBL8136134 0.70 ALDH1A1 (0.55) SQORKDM4EALDH1A1NPC1GAA
SCHEMBL7022233 0.70 SQOR (0.57) SQORHTTADORA2AHSD17B10ADRA2A
SCHEMBL1421642 0.70 SQOR (0.56) SQORHTTADORA2AHSD17B10ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1706412-A4 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS CO LTD (KR) 2009-03-18 EP disclosed
EP-1706412-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK Chemicals, Co., Ltd. (KR) 2006-10-04 EP disclosed
WO-2005063768-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS, CO., LTD. (KR) 2005-07-14 WO disclosed