Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LAP3 | P28838 | 3/20 | 0.56 |
| ▸ | ANPEP | P15144 | 1/20 | 0.56 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.56 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 3/20 | 0.51 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679505 | 0.91 | LAP3 (0.70) | LAP3ANPEPRNPEPDNPEPREN | |
| SCHEMBL7589901 | 0.91 | LAP3 (0.70) | LAP3ANPEPRNPEPDNPEPREN | |
| SCHEMBL4043571 | 0.76 | REN (0.63) | CYP3A4TSHRLAP3ANPEPRNPEP | |
| SCHEMBL7394875 | 0.76 | LAP3 (0.46) | CYP3A4LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL4068036 | 0.76 | REN (0.62) | LAP3RENCCR1 | |
| SCHEMBL4066989 | 0.76 | REN (0.62) | LAP3RENCCR1 | |
| SCHEMBL28724369 | 0.75 | LAP3 (0.52) | CYP3A4TSHRLAP3ANPEPRNPEP | |
| SCHEMBL14372988 | 0.75 | CYP3A4 (0.58) | CYP3A4TSHRANPEP | |
| SCHEMBL3534809 | 0.75 | REN (0.85) | REN | |
| SCHEMBL3534806 | 0.75 | REN (0.85) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |