Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315498 | 0.71 | MAPT (0.53) | NPC1RAB9AUSP2SMN1; SMN2MAPK1 | |
| SCHEMBL704966 | 0.71 | MMP12 (0.55) | ABL1CES1LMNAPKMSMN1; SMN2 | |
| SCHEMBL6757684 | 0.68 | KIF11 (0.50) | PIM1CES1 | |
| SCHEMBL31560396 | 0.67 | PTGS1 (0.49) | PIM1PTGS1PTGS2TP53GAA | |
| SCHEMBL12316591 | 0.66 | GRM5 (0.45) | CHRM5CES1PTGS1PTGS2SCN4A | |
| SCHEMBL1208429 | 0.65 | PTGS1 (0.56) | PIM1PTGS1PTGS2TP53GAA | |
| SCHEMBL3881419 | 0.65 | MAOA (0.58) | CES1LMNAGAAKCNH2GPR3 | |
| SCHEMBL2953372 | 0.64 | HTT (0.62) | USP2CYP1A2CYP3A4KCNH2 | |
| SCHEMBL14775775 | 0.63 | PTGS1 (0.51) | PIM1PTGS1PTGS2 | |
| SCHEMBL2054544 | 0.63 | PTGS1 (0.42) | CHRM5PTGS1PTGS2GPR3CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |