Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.43 |
| ▸ | LIPE | Q05469 | 9/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067942 | 0.84 | LIPE (0.46) | ITGB3ITGA2BLIPE | |
| SCHEMBL4072091 | 0.82 | ITGB3 (0.51) | ITGB3ITGA2BLIPEMETAP2 | |
| SCHEMBL18208417 | 0.80 | HRH3 (0.52) | LIPEEBP | |
| SCHEMBL20103121 | 0.78 | HRH3 (0.48) | ITGB3ITGA2BLIPEEBP | |
| SCHEMBL18208920 | 0.77 | EBP (0.44) | ITGB3ITGA2BLIPEEBP | |
| SCHEMBL12342523 | 0.76 | HRH3 (0.45) | ITGB3ITGA2BLIPEEBP | |
| Hydrochloric Acid SCHEMBL2336913 | 0.74 | HRH3 (0.44) | ITGB3ITGA2BLIPEEBP | |
| SCHEMBL20205235 | 0.74 | LIPE (0.52) | LIPEEBP | |
| SCHEMBL17328518 | 0.73 | METAP2 (0.56) | METAP2 | |
| SCHEMBL17328532 | 0.73 | METAP2 (0.56) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | claimed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | claimed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |