Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30761205 | 0.69 | DPYD (0.42) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL22114527 | 0.68 | PKM (0.54) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL4351095 | 0.63 | GSK3B (0.41) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL10037027 | 0.63 | DPYD (0.47) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL4748506 | 0.63 | DYRK1A (0.37) | DPYDMCL1DYRK1ACHUKLRRK2 | |
| SCHEMBL11025589 | 0.63 | IMPDH2 (0.60) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL189451 | 0.63 | DPYD (1.00) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL21333260 | 0.61 | MCL1 (0.55) | DPYDMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL8305565 | 0.61 | MCL1 (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL16418590 | 0.60 | MCL1 (0.49) | DPYDMCL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-2027093-A2 | SUBSTITUTED CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007146323-A2 | SUBSTITUTED CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146376-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |