SCHEMBL4748506

SCHEMBL4748506

N#Cc1c[nH]c(C(F)(F)F)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 2/20 0.37
LRRK2 Q5S007 2/20 0.35
DPYD Q12882 1/20 0.34
AR P10275 12/20 0.34
CHUK O15111 1/20 0.34
IMPDH2 P12268 1/20 0.33
IMPDH1 P20839 1/20 0.33
MCL1 Q07820 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28034518 0.75 KDM4E (0.36) DYRK1ALRRK2ARMCL1
SCHEMBL28034516 0.74 AR (0.33) DYRK1ALRRK2ARMCL1
SCHEMBL28035135 0.74 DYRK1A (0.35) DYRK1ALRRK2AR
SCHEMBL9023027 0.74 MCL1 (0.44) DYRK1ALRRK2ARMCL1
SCHEMBL30761205 0.71 DPYD (0.42) DYRK1ALRRK2DPYDCHUKMCL1
SCHEMBL9023323 0.69 MCL1 (0.41) DYRK1ALRRK2ARCHUKIMPDH2
SCHEMBL28035241 0.68 CHUK (0.42) ARCHUK
SCHEMBL8374867 0.67 KIF11 (0.36) ARIMPDH2IMPDH1MCL1
SCHEMBL28035243 0.66 CHUK (0.44) LRRK2ARCHUKIMPDH2IMPDH1
SCHEMBL9121134 0.65 KDM4E (0.40) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080293848-A1 SELF-POLISHING ANTI-FOULING COMPOSITIONS THE SHERWIN-WILLIAMS COMPANY (US) 2008-11-27 US disclosed
WO-2008121308-A1 SELF-POLISHING ANTI-FOULING COMPOSITIONS THE SHERWIN-WILLIAMS COMPANY (US) 2008-10-09 WO disclosed
EP-1675919-A1 SELF-POLISHING ANTI-FOULING COMPOSITIONS THE SHERWIN-WILLIAMS COMPANY (US) 2006-07-05 EP disclosed
WO-2005042649-A1 SELF-POLISHING ANTI-FOULING COMPOSITIONS THE SHERWIN-WILLIAMS COMPANY (US) 2005-05-12 WO disclosed
US-20050096407-A1 Self-polishing anti-fouling compositions SHERWIN-WILLIAMS COMPANY, THE 2005-05-05 US disclosed