Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29067937 | 0.79 | ANPEP (0.33) | — | |
| SCHEMBL29067935 | 0.79 | ANPEP (0.33) | — | |
| SCHEMBL9184 | 0.72 | PSEN1 (0.35) | MGLLPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8001064 | 0.72 | CTSS (0.34) | MGLLPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8206969 | 0.71 | PDE8B (0.30) | — | |
| SCHEMBL8007880 | 0.71 | PDE8B (0.30) | — | |
| SCHEMBL15049751 | 0.71 | MGLL (0.30) | MGLL | |
| SCHEMBL4071173 | 0.71 | CYP2D6 (0.33) | — | |
| SCHEMBL2027347 | 0.71 | CYP2D6 (0.33) | — | |
| SCHEMBL7887860 | 0.70 | GRIN2D (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074108-A1 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008036247-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |