Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 3/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13710937 | 0.80 | CTSK (0.42) | CTSSCTSLCPB2MMP1MMP2 | |
| SCHEMBL3617417 | 0.80 | CTSK (0.42) | CTSSCTSLCPB2MMP1MMP2 | |
| SCHEMBL13711061 | 0.80 | CTSK (0.42) | CTSSCTSLCPB2MMP1MMP2 | |
| SCHEMBL9184 | 0.80 | PSEN1 (0.35) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24668365 | 0.78 | CNR2 (0.40) | CTSSCNR2CPB2MMP1MMP2 | |
| SCHEMBL15107681 | 0.76 | REN (0.35) | BRD4REN | |
| SCHEMBL15061786 | 0.74 | BRD4 (0.30) | BRD4 | |
| SCHEMBL8220745 | 0.73 | REN (0.31) | REN | |
| SCHEMBL4072253 | 0.72 | MGLL (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7887860 | 0.71 | GRIN2D (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009154766-A1 | RENIN INHIBITORS AND METHOD OF USE THEREOF | VITAE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |