Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078270 | 0.90 | RXRA (0.46) | RXRAKIF11PPARGNR1H3HTT | |
| SCHEMBL647102 | 0.88 | IL2 (0.41) | RXRAKDM4EFGFR1CRACR2ARAB9A | |
| SCHEMBL648476 | 0.87 | GABRA5 (0.38) | RXRAKIF11KDM4EFGFR1ACSS2 | |
| SCHEMBL648270 | 0.85 | ALDH1A1 (0.43) | RXRAKIF11KDM4EFGFR1ALDH1A1 | |
| SCHEMBL647040 | 0.84 | KIF11 (0.41) | RXRAKIF11KDM4EIDH1 | |
| SCHEMBL647099 | 0.82 | RXRA (0.37) | RXRAKIF11KDM4EFGFR1PPARG | |
| SCHEMBL647190 | 0.82 | STIM1 (0.38) | RXRAKIF11KDM4EPPARGNR1H3 | |
| SCHEMBL645412 | 0.82 | RXRA (0.37) | RXRAKIF11KDM4EFGFR1PPARG | |
| SCHEMBL647445 | 0.81 | IDH1 (0.37) | RXRAKDM4EPPARGNR1H3IDH1 | |
| SCHEMBL645940 | 0.81 | IDH1 (0.37) | RXRAKDM4EPPARGNR1H3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |