Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407322 | 0.80 | PDK1 (0.59) | PDK1LIMK1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL439305 | 0.78 | CDC7 (0.35) | PDK1CDC7DBF4LIMK1HTT | |
| SCHEMBL1700743 | 0.77 | PDK1 (0.74) | PDK1LIMK1GAAHTTRECQL | |
| SCHEMBL17385025 | 0.76 | PDK1 (0.73) | PDK1LIMK1GAARECQLHSD17B10 | |
| SCHEMBL408331 | 0.76 | PDK1 (0.59) | PDK1CDC7DBF4LIMK1HSD17B10 | |
| SCHEMBL22677886 | 0.75 | PDK1 (0.71) | PDK1LIMK1GAARECQLHSD17B10 | |
| SCHEMBL1030772 | 0.75 | PDK1 (0.71) | PDK1LIMK1GAAHTTHSD17B10 | |
| SCHEMBL14311264 | 0.74 | PDK1 (0.60) | PDK1LIMK1ALDH1A1KDM4EGSK3B | |
| Bromide SCHEMBL1030770 | 0.74 | PDK1 (0.70) | PDK1LIMK1GAAHTTHSD17B10 | |
| SCHEMBL406838 | 0.73 | PDK1 (0.68) | PDK1LIMK1GAARECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| WO-2008011130-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | DGAT2, DGAT1, DLAT | PDK1 377/4885CDC7 3124/4885DBF4 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.