SCHEMBL4074344

SCHEMBL4074344

COc1cc(N2CCC(C(Cl)C=O)CC2)c(Cl)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 5/20 0.47
MALT1 Q9UDY8 1/20 0.38
PPOX P50336 1/20 0.38
ALDH1A1 P00352 6/20 0.38
MAPT P10636 5/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
MAPK1 P28482 2/20 0.37
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HSP90AA1 P07900 1/20 0.37
PKM P14618 1/20 0.37
RAB9A P51151 1/20 0.37
CCR6 P51684 1/20 0.37
CACNA1B Q00975 1/20 0.37
APBA1 Q02410 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
APOBEC3G Q9HC16 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4076129 0.81 CCR1 (0.50) CCR1ALDH1A1MAPTLMNA
SCHEMBL3227831 0.77 CCR1 (0.49) CCR1MALT1PPOXMAPTHPGD
SCHEMBL3227912 0.76 CCR1 (0.50) CCR1MALT1PPOXALDH1A1MAPT
SCHEMBL3225808 0.75 POLB (0.59) ALDH1A1MAPTMAPK1LMNASMN1; SMN2
SCHEMBL3223360 0.72 ALDH1A1 (0.47) CCR1PPOXALDH1A1MAPTCYP1A2
SCHEMBL3224081 0.72 MALT1 (0.48) CCR1MALT1ALDH1A1TSHR
SCHEMBL2874775 0.70 HTR3A (0.60) MAPTCYP2C19LMNAHTR2CHTR6
SCHEMBL5048385 0.70 CCR1 (0.41) CCR1ALDH1A1MAPTMAPK1LMNA
Hydrochloric Acid SCHEMBL5051976 0.69 CCR1 (0.41) CCR1ALDH1A1MAPTMAPK1LMNA
Hydrochloric Acid SCHEMBL2870719 0.69 HTR3A (0.59) MAPTCYP2C19LMNAHTR2CHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2084146-A1 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Brystol-Myers Squibb Company (US) 2009-08-05 EP disclosed
WO-2008042925-A1 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2008-04-10 WO disclosed