Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074320 | 0.91 | MAPK14 (0.37) | OPRM1OPRD1OPRK1NAMPTEGLN1 | |
| SCHEMBL4256842 | 0.89 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1CHRM2 | |
| SCHEMBL4081761 | 0.89 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1NAMPT | |
| SCHEMBL4481852 | 0.85 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1EGLN1 | |
| SCHEMBL4483783 | 0.83 | OPRM1 (0.56) | OPRM1OPRD1OPRK1OPRL1CHRM2 | |
| SCHEMBL4075640 | 0.80 | BACE1 (0.39) | OPRM1OPRD1OPRK1EGLN1KLKB1 | |
| SCHEMBL4080173 | 0.80 | CYP2C9 (0.47) | OXTRAVPR1AMAPK14AVPR2AVPR1B | |
| SCHEMBL4078534 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1MAPK14 | |
| Hydrochloric Acid SCHEMBL4074231 | 0.78 | OPRM1 (0.41) | OPRM1OPRD1OPRK1MAPK14 | |
| SCHEMBL4080420 | 0.77 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |