Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | CHUK | O15111 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 3/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071701 | 0.93 | OPRM1 (0.47) | OPRM1OPRD1OPRK1RARBMAPK14 | |
| SCHEMBL4483783 | 0.92 | OPRM1 (0.56) | OPRM1OPRD1OPRK1CHUKMAPK8 | |
| SCHEMBL4083677 | 0.88 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MAPK1CHEK2 | |
| SCHEMBL4256842 | 0.85 | OPRM1 (0.45) | OPRM1OPRD1OPRK1EGLN1CHEK2 | |
| SCHEMBL4074406 | 0.85 | OPRM1 (0.46) | OPRM1OPRD1OPRK1EGLN1CHEK2 | |
| SCHEMBL4075945 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MAPK1CHEK2 | |
| SCHEMBL4492023 | 0.82 | OPRM1 (0.45) | OPRM1OPRD1OPRK1CHUKMAPK8 | |
| SCHEMBL1790195 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OXTRAVPR1A | |
| SCHEMBL4078358 | 0.78 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL3342460 | 0.78 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |