Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256842 | 0.92 | OPRM1 (0.45) | BACE1MAPK14KLKB1OXTRAVPR1A | |
| SCHEMBL4074320 | 0.88 | MAPK14 (0.37) | BACE1MAPK14KLKB1CYP2C9OXTR | |
| SCHEMBL4492023 | 0.80 | OPRM1 (0.45) | HDAC6EGLN1CHEK2OPRM1OPRD1 | |
| SCHEMBL4080420 | 0.80 | OPRM1 (0.45) | KLKB1CHEK2OPRM1OPRD1OPRK1 | |
| SCHEMBL4074406 | 0.80 | OPRM1 (0.46) | MAPK14KLKB1OXTRAVPR1AEGLN1 | |
| SCHEMBL4079230 | 0.78 | OPRM1 (0.40) | MAPK14HDAC1KLKB1MPLBDKRB1 | |
| SCHEMBL4481852 | 0.76 | OPRM1 (0.57) | MAPK14OXTRAVPR1AEGLN1CHEK2 | |
| SCHEMBL4074327 | 0.75 | OPRM1 (0.56) | HDAC1KLKB1MPLBDKRB1OPRM1 | |
| SCHEMBL4080173 | 0.74 | CYP2C9 (0.47) | MAPK14CYP2C9OXTRAVPR1AKDM4E | |
| SCHEMBL4483783 | 0.71 | OPRM1 (0.56) | EGLN1CHEK2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |