Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075641 | 0.85 | OPRM1 (0.52) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| SCHEMBL4080426 | 0.85 | OPRM1 (0.48) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4475141 | 0.84 | OPRM1 (0.51) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| SCHEMBL4253659 | 0.81 | OPRM1 (0.46) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| SCHEMBL4073644 | 0.81 | OPRM1 (0.53) | OPRM1OPRK1OPRD1SMN1; SMN2HDAC1 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.80 | OPRM1 (0.52) | OPRM1OPRK1OPRD1SMN1; SMN2HDAC1 | |
| SCHEMBL13633134 | 0.80 | OPRK1 (0.41) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4072865 | 0.79 | OPRK1 (0.40) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| SCHEMBL4496256 | 0.78 | OPRM1 (0.52) | OPRM1OPRK1OPRD1SMN1; SMN2LMNA | |
| SCHEMBL4074922 | 0.77 | KMT2A (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |