Sugi Predict

Sugi Predict / Compounds / SCHEMBL4074477

SCHEMBL4074477

SCHEMBL4074477

CCOC(=O)c1cn([Si](C)(C)C)cn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.50
▸ CYP1A2 P05177 1/20 0.46
▸ ALDH1A1 P00352 4/20 0.44
▸ KDM4E B2RXH2 3/20 0.44
▸ HPGD P15428 1/20 0.44
▸ GAA P10253 1/20 0.42
▸ POLB P06746 1/20 0.41
▸ GABRA2 P47869 5/20 0.40
▸ GABRB2 P47870 5/20 0.40
▸ LMNA P02545 1/20 0.40
▸ MAPT P10636 2/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ GLA P06280 1/20 0.39
▸ GABRP O00591 1/20 0.39
▸ GABRD O14764 1/20 0.39
▸ GABRA1 P14867 1/20 0.39
▸ GABRB1 P18505 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5591480 0.79 NOTUM (0.52) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL25153647 0.78 NOTUM (0.51) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL12458255 0.75 NOTUM (0.49) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL28934829 0.75 NOTUM (0.49) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL16268515 0.75 NOTUM (0.49) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL25868326 0.75 NOTUM (0.49) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL14151307 0.74 NOTUM (0.48) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL28934757 0.74 NOTUM (0.48) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL24036185 0.74 NOTUM (0.48) NOTUMCYP1A2ALDH1A1KDM4EHPGD
SCHEMBL15148626 0.73 NOTUM (0.47) NOTUMCYP1A2ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7491818-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2009-02-17 — — US disclosed
US-7423143-B2 Nucleic acid labeling compounds AFFYMETRIX. INC. (US) 2008-09-09 — — US disclosed
US-7291463-B2 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2007-11-06 — — US disclosed
US-7282327-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-10-16 — — US disclosed
US-7179905-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-02-20 — — US disclosed
US-20050287563-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-12-29 — — US disclosed
US-6965020-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2005-11-15 — — US disclosed
EP-1589025-A2 Nucleic acid labeling compounds Affymetrix, Inc. (US) 2005-10-26 — — EP disclosed
US-20050164268-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-07-28 — — US disclosed
EP-1124838-B1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX INC (US) 2005-06-01 — — EP disclosed
US-20040002595-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-01-01 — — US disclosed
US-20030232979-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-12-18 — — US disclosed
US-20030180757-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-09-25 — — US disclosed
US-6596856-B2 For probes, comprising a heterocycle condensed with a cyclic group such as ribofuranose derivative; biotin and 5-carboxyfluorescein derivatives AFFYMETRIX, INC. 2003-07-22 — — US disclosed
US-20020165372-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2002-11-07 — — US disclosed
WO-2000006771-A9 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX INC (US) 2002-08-22 — — WO disclosed
US-20010044531-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2001-11-22 — — US disclosed
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. 2001-08-30 — — US disclosed
EP-1124838-A2 NUCLEIC ACID LABELING COMPOUNDS Affymetrix, Inc. (US) 2001-08-22 — — EP disclosed
WO-2000006771-A2 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. (US) 2000-02-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040002595-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20030180757-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20050164268-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20010044531-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20050287563-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20020165372-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885
US-20030232979-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL NOTUM 2632/4885CYP1A2 3633/4885ALDH1A1 760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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