SCHEMBL407452

SCHEMBL407452

CCc1ccc(Br)cc1C(O)c1ccco1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.38
OPRM1 P35372 1/20 0.38
OPRD1 P41143 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.37
POLB P06746 2/20 0.37
PKM P14618 1/20 0.37
PTPN1 P18031 1/20 0.37
PTPN7 P35236 1/20 0.37
BLM P54132 1/20 0.37
ESR2 Q92731 1/20 0.37
MAPT P10636 3/20 0.36
MEN1 O00255 2/20 0.36
HPGD P15428 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
AGTR1 P30556 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
ALOX12 P18054 1/20 0.34
GLA P06280 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL515563 0.88 KMT2A (0.38) KMT2AOPRM1OPRD1L3MBTL1POLB
SCHEMBL16398303 0.80 KMT2A (0.36) KMT2AOPRM1OPRD1L3MBTL1POLB
SCHEMBL432518 0.79 KMT2A (0.36) KMT2AL3MBTL1POLBPKMPTPN1
SCHEMBL20299216 0.73 KMT2A (0.41) KMT2APOLBMAPTMEN1HPGD
SCHEMBL25908131 0.70 GABRA1 (0.43) L3MBTL1MAPTHPGDALDH1A1TDP1
SCHEMBL27848706 0.69 PIK3R1 (0.44) KMT2AL3MBTL1POLBPTPN1BLM
SCHEMBL20139451 0.69 KMT2A (0.42) KMT2AL3MBTL1MAPTMEN1ALDH1A1
SCHEMBL16958722 0.67 EDNRB (0.35) L3MBTL1MAPTHPGDTDP1SMN1; SMN2
SCHEMBL16956297 0.67 L3MBTL1 (0.33) L3MBTL1POLBMAPTHPGDKDM4E
SCHEMBL10187529 0.67 KMT2A (0.38) KMT2AOPRM1OPRD1L3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 EP disclosed
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 EP disclosed
EP-2173755-B1 NOVEL HERBICIDES SYNGENTA LTD (GB) 2017-05-17 EP disclosed
EP-2173755-B1 NOVEL HERBICIDES SYNGENTA LTD (GB) 2017-05-17 EP disclosed
US-8940913-B2 Herbicides SYNGENTA CROP PROTECTION, LLC (US) 2015-01-27 US disclosed
US-8940913-B2 Herbicides SYNGENTA CROP PROTECTION, LLC (US) 2015-01-27 US disclosed
US-8940913-B2 Herbicides SYNGENTA CROP PROTECTION, LLC (US) 2015-01-27 US disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 US disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 US disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 US disclosed
WO-2010133232-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-11-25 WO disclosed
WO-2010133232-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-11-25 WO disclosed
WO-2010102848-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LIMITED (GB) 2010-09-16 WO disclosed
WO-2010102848-A1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LIMITED (GB) 2010-09-16 WO disclosed
EP-2185564-A2 TRICYCLIC BRIDGED CYCLOPENTANEDIONE DERIVATIVES AS HERBICIDES Syngenta Limited (GB) 2010-05-19 EP disclosed
EP-2173755-A1 NOVEL HERBICIDES Syngenta Limited (GB) 2010-04-14 EP disclosed
WO-2009019015-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2009-02-12 WO disclosed
WO-2009019015-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2009-02-12 WO disclosed
WO-2009019005-A2 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2009-02-12 WO disclosed
WO-2009019005-A2 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2009-02-12 WO disclosed