Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087525 | 0.91 | MAPT (0.55) | LTA4HMAPK14PLAUPLATMAPT | |
| SCHEMBL29380769 | 0.88 | MAPT (0.57) | LTA4HMAPK14PLAUPLATMAPT | |
| SCHEMBL416462 | 0.88 | MAPT (0.57) | LTA4HMAPK14PLAUPLATMAPT | |
| SCHEMBL365975 | 0.86 | ABCB1 (0.48) | IDO1EP300KAT8LTA4HMAPK14 | |
| SCHEMBL11973262 | 0.80 | LTA4H (0.58) | IDO1LTA4HMAPK14PLAUPLAT | |
| SCHEMBL6600225 | 0.80 | LTA4H (0.58) | IDO1LTA4HMAPK14PLAUPLAT | |
| SCHEMBL3157216 | 0.79 | MRGPRX4 (0.66) | IDO1MAPTL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL10607164 | 0.79 | HTR1A (0.58) | PLAUPLATMAPTL3MBTL1RAB9A | |
| SCHEMBL1979771 | 0.79 | IDO1 (0.44) | IDO1EP300KAT8LTA4HMAPK14 | |
| SCHEMBL31086650 | 0.79 | IDO1 (0.44) | IDO1EP300KAT8LTA4HMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927085-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | HUEN CO., LTD. (KR) | 2021-02-23 | — | — | US | disclosed |
| US-20160376243-A1 | 1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME | KT&G LIFE SCIENCES CORPORATION (KR) | 2016-12-29 | — | — | US | disclosed |
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |
| US-20140235702-A1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF | WAYNE STATE UNIVERSITY | 2014-08-21 | — | — | US | disclosed |
| US-7482339-B2 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | IDO1 600/4885EP300 1212/4885KAT8 2260/4885 |
| US-20140235702-A1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF | MCL1, BCL2L1, BCL2L11 | IDO1 2378/4885EP300 3568/4885KAT8 3510/4885 |
| US-10927085-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | UGT1A6, CYP2D6, SLC5A1 | IDO1 2412/4885EP300 2951/4885KAT8 3224/4885 |
| US-20160376243-A1 | 1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME | CYP2S1, SLC5A1, CYP2D6 | IDO1 2275/4885EP300 3094/4885KAT8 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.