Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27868891 | 0.82 | GPR119 (0.45) | HSD11B1RIPK1PRMT5WDR77 | |
| SCHEMBL29773951 | 0.82 | GPR119 (0.45) | HSD11B1RIPK1PRMT5WDR77 | |
| SCHEMBL28938508 | 0.82 | HSD11B1 (0.40) | HSD11B1RIPK1SIGMAR1 | |
| SCHEMBL1434923 | 0.82 | HTR2C (0.40) | HSD11B1RIPK1SIGMAR1PRMT5WDR77 | |
| SCHEMBL16796971 | 0.82 | RIPK1 (0.40) | HSD11B1RIPK1SIGMAR1BTK | |
| SCHEMBL4078027 | 0.81 | DPP4 (0.43) | RIPK1 | |
| SCHEMBL5321655 | 0.81 | RIPK1 (0.40) | RIPK1SIGMAR1BTK | |
| SCHEMBL8499875 | 0.81 | RIPK1 (0.40) | RIPK1SIGMAR1PRMT5WDR77 | |
| SCHEMBL29091782 | 0.78 | RIPK1 (0.39) | HSD11B1RIPK1SIGMAR1PRMT5WDR77 | |
| SCHEMBL5229321 | 0.76 | GPR119 (0.43) | HSD11B1RIPK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |