Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953894 | 0.83 | ALDH1A1 (0.48) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4073512 | 0.79 | POLB (0.43) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3953576 | 0.72 | ALDH1A1 (0.46) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3953725 | 0.71 | ALDH1A1 (0.48) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3952843 | 0.71 | ALDH1A1 (0.53) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3956925 | 0.69 | GRM5 (0.40) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3951443 | 0.69 | GABRA5 (0.47) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4075384 | 0.69 | ALOX5 (0.44) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3952855 | 0.69 | GABRA5 (0.51) | HPGDTP53MEN1KMT2APOLB | |
| SCHEMBL3953504 | 0.68 | KMT2A (0.48) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029559-B1 | ARYL-4-ETHYNYL-ISOXAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-05 | — | — | EP | claimed |