SCHEMBL4075384

SCHEMBL4075384

CCOC(=O)Oc1nc(C)sc1C#Cc1c(-c2ccccc2)noc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.44
CACNA1F O60840 1/20 0.42
CACNA1D Q01668 1/20 0.42
CACNA1S Q13698 1/20 0.42
CACNA1C Q13936 1/20 0.42
ALDH1A1 P00352 5/20 0.40
HSD17B10 Q99714 2/20 0.40
HPGD P15428 2/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 2/20 0.40
PTBP1 P26599 1/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
GABRA5 P31644 1/20 0.39
TSHR P16473 2/20 0.39
ADORA3 P0DMS8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3953400 0.84 ALDH1A1 (0.47) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL4083809 0.76 CACNA1F (0.42) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL3956220 0.69 GABRA5 (0.46) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL4075379 0.69 LMNA (0.44) ALDH1A1HPGDLMNASMN1; SMN2KDM4E
SCHEMBL4073512 0.69 POLB (0.43) ALDH1A1HSD17B10HPGDLMNASMN1; SMN2
SCHEMBL10970985 0.66 ALOX5 (0.53) ALOX5ALDH1A1HSD17B10HPGDLMNA
SCHEMBL3953576 0.66 ALDH1A1 (0.46) ALDH1A1HSD17B10HPGDLMNASMN1; SMN2
SCHEMBL3953894 0.66 ALDH1A1 (0.48) ALDH1A1HSD17B10HPGDLMNASMN1; SMN2
SCHEMBL3954298 0.66 KMT2A (0.48) ALDH1A1LMNASMN1; SMN2KDM4EMEN1
SCHEMBL3953504 0.66 KMT2A (0.48) ALDH1A1LMNASMN1; SMN2KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029559-B1 ARYL-4-ETHYNYL-ISOXAZOLE DERIVATIVES HOFFMANN LA ROCHE (CH) 2009-08-05 EP claimed